- Glikobiałko z błony ludzkich erytrocytów zostało zidentyfikowane jako receptor dla C3b (CR1). Promuje dysocjację konwertazy C3b,Bb szlaku alternatywnego C3 i rozszczepianie C3b przez inaktywator C3b/ C4b . Odkryliśmy, że CR1 dezaktywuje również konwertazy C3 i C5 szlaku klasycznego. CR1 hamuje zużycie C3 przez konwertazę C3 EAC142 i wzmaga rozpad miejsc C4b ,2a. Na podstawie masy, CR1 jest około 5-10 razy bardziej aktywny niż białko wiążące C4 , inhibitor surowicy C4b ,2a.
- Wiązanie 125I-CR1 z komórkami EAC14 jest hamowane przez C2. Dlatego jest prawdopodobne, że CR1 i C2 konkurują o witrynę na C4b . CR1 hamował konwertazę C5 jeszcze skuteczniej, ale nie miał wpływu na tworzenie się składników późnego dopełniacza .
- W wysokich stężeniach sam CR1 nie ma nieodwracalnego wpływu na C4b związany z komórką . W fazie płynnej CR1 może działać jako kofaktor rozszczepiania łańcucha alfa’ C4b przez inaktywator C3b/ C4b . Dobrze znaną funkcją CR1 jest promowanie przylegania drobnoustrojów lub kompleksów immunologicznych niosących C3b i C4b do komórek.
- Ta interakcja może skutkować uszkodzeniem mikrośrodowiska błony plazmatycznej komórki odpowiadającej, ponieważ zewnętrzne fragmenty C3b i C4b mogą służyć jako dodatkowe miejsca gromadzenia się enzymów kaskady.
- Dlatego chcielibyśmy zaproponować, aby CR1 na powierzchni komórek dostarczał zwiększone miejscowe stężenie silnego inhibitora enzymów amplifikujących układu dopełniacza i zapewniał komórkom mechanizm omijania uszkodzeń, gdy wiążą substraty niosące C3b i C4b .
Oczyszczanie i charakteryzacja białka błonowego (gp45-70), które jest kofaktorem cięcia C3b i C4b .
- W oparciu o wstępne dowody wskazujące, że związane z komórką białko U937 ( ludzka linia komórkowa podobna do monocytów) posiada aktywność kofaktora i nie jest receptorem C3b/ C4b , staraliśmy się dalej scharakteryzować to białko .
- Opracowano sekwencyjną czterokolumnową procedurę oczyszczania, która obejmuje chromatografię powinowactwa C3(H2O) w celu wyizolowania z rozsądną wydajnością i czystością związanego z komórką białka U937 i kilku innych ludzkich linii komórkowych. W oparciu o jego wzór i Mr na SDS-PAGE, kwasowym pI i specyficzności wobec liganda, jest on identyczny z niedawno opisanym glikoproteiną błonową wiążącą C3(H2O) lub C3b z ludzkich PBL i linii komórkowych; nie mając obecnie zidentyfikowanej funkcji, nazwano go gp45-70.
- Po oczyszczeniu tego białka określiliśmy jego możliwości funkcjonalne i porównaliśmy je z innymi białkami dopełniacza o aktywności regulacyjnej skierowanej na składniki zawierające konwertazy C3.
- Białko to było najbardziej wydajnym (50 razy bardziej niż H) dotychczas opisanym kofaktorem dla pierwszego cięcia C3b za pośrednictwem I. Był również kofaktorem dla pierwszego cięcia C4b , ale nie był tak wydajny jak C4b p. Drugie cięcie C3b i C4b nie było skutecznie mediowane.
- Nie miał zdolności do przyspieszania rozpadu w konwertazach C3 szlaku klasycznego lub alternatywnego. W oparciu o ten unikalny profil aktywności i zdolność do znakowania powierzchniowego zmieniliśmy nazwę tej cząsteczki na białko kofaktor błonowy (MCP). Sugerujemy, że białko to odgrywa główną rolę w zapobieganiu autologicznej aktywacji dopełniacza .
Wewnętrzny tioester i kowalencyjne właściwości wiązania białek dopełniacza C3 i C4.
- Wiązanie kowalencyjne składników dopełniacza C3 i C4 ma kluczowe znaczenie dla ich aktywności. Ta reakcja jest możliwa dzięki obecności wewnętrznego tioestru w natywnym białku . Po aktywacji, która obejmuje zmianę konformacyjną zapoczątkowaną przez rozszczepienie pojedynczego wiązania peptydowego, tioester staje się dostępny do reagowania z cząsteczkami z grupami nukleofilowymi.
- Ten opis jest prawdopodobnie wystarczający do wyjaśnienia wiązania izotypu C4A ludzkiego C4 z aminonukleofilami. Wiązanie izotypu C4B i najprawdopodobniej C3 z nukleofilami hydroksylowymi obejmuje jednak resztę histydynową, która atakuje tioester, tworząc wewnątrzcząsteczkowe wiązanie acylo-imidazolowe.
- Uwolniony anion tiolanowy działa następnie jako zasada katalizując wiązanie nukleofilów hydroksylowych, w tym wody, z funkcją acylową.
- Mechanizm ten umożliwia białkom dopełniacza wiązanie się z grupami hydroksylowymi węglowodanów znajdujących się na wszystkich powierzchniach biologicznych, w tym w składnikach ścian komórkowych bakterii. Ponadto szybka hydroliza tioestru zapewnia środki do powstrzymania tej bardzo szkodliwej reakcji w bezpośredniej bliskości miejsca aktywacji.
Wiązanie C4b – białka wiążącego do poryny : molekularny mechanizm oporności surowicy Neisseria gonorrhoeae.
- Przebadaliśmy 29 szczepów Neisseria gonorrhoeae i znaleźliśmy 16/21 szczepów odpornych na zabijanie przez normalną ludzką surowicę i 0/8 szczepów wrażliwych na surowicę, które wiązały regulator dopełniacza , białko wiążące C4b ( C4b p ).
- Mikrobiologiczny C4b p związany z powierzchnią wykazał aktywność kofaktora. Skonstruowaliśmy szczepy gonokokowe z hybrydowymi cząsteczkami porin (Por) pochodzącymi z każdej z głównych grup serologicznych (Por1A i Por1B) N. gonorrhoeae i wykazaliśmy, że pętla 1 Por1A jest wymagana do wiązania C4b p . Pętle Por1B 5 i 7 gonokoków opornych na surowicę razem tworzyły ujemnie naładowaną domenę wiążącą p C4b . Oddziaływania C4b p-Por1B miały charakter jonowy (hamowane przez wysokie stężenie soli lub heparynę), podczas gdy wiązanie C4b p-Por1A było hydrofobowe.
- Jedynie zrekombinowane zmutowane cząsteczki C4b p zawierające NH2-końcowe krótkie konsensusowe powtórzenie łańcucha alfa (SCR1) związane z gonokokami Por1A i Por1B, co sugeruje, że SCR1 zawiera miejsca wiązania Por . Monomery z łańcuchem alfa C4b p nie wiązały gonokoków, co wskazuje, że polimeryczna forma C4b p była wymagana do wiązania .
- Stosując fragmenty fAb przeciwko C4b p SCR1, wiązanie C4b p ze szczepami Por1A i Por1B zostało zahamowane w teście bakteriobójczym surowicy zależnym od dopełniacza .
- Doprowadziło to do całkowitego zabicia tych skądinąd całkowicie opornych na surowicę szczepów tylko w 10% normalnej surowicy, podkreślając znaczenie C4b p w pośredniczeniu w oporności na gonokoki w surowicy.
Białko regulatorowe dopełniacza myszy Crry/p65 wykorzystuje specyficzne mechanizmy zarówno ludzkiego czynnika przyspieszającego rozpad, jak i białka kofaktora błonowego .
- Normalne komórki gospodarza są chronione przed destrukcyjnym działaniem dopełniacza przez białka regulatorowe dopełniacza znajdujące się na powierzchni komórki . U ludzi czynnik przyspieszający rozpad (DAF) i białko kofaktora błonowego (MCP) odgrywają taką biologiczną rolę, hamując konwertazy C3 i C5. DAF i MCP realizują to zadanie dzięki specyficznym mechanizmom, określanym odpowiednio jako aktywność przyspieszająca rozpad i aktywność kofaktora czynnika I.
- U innych gatunków, w tym myszy, strukturalne i/lub funkcjonalne homologi tych białek nie są jeszcze dobrze scharakteryzowane. Wcześniejsze badania wykazały, że mysie białko Crry/p65 ma pewne cechy samoochronnych białek regulatorowych dopełniacza .
- Na przykład, Crry/p65 ulega ekspresji na wielu różnych komórkach mysich, a przy ekspresji na ludzkich komórkach erytroleukemicznych K562 zapobiega odkładaniu się mysich fragmentów C3 na powierzchni komórki podczas aktywacji klasycznego lub alternatywnego szlaku dopełniacza . Zbadaliśmy teraz kofaktor czynnika I i przyspieszającą rozpad aktywność Crry/p65.
- Rekombinowany Crry/p65 wykazuje aktywność kofaktora dla cięcia za pośrednictwem czynnika I zarówno mysiego C3b, jak i C4b . Co zaskakujące, Crry/p65 wykazuje również silnie przyspieszającą rozpad aktywność konwertazy C3 szlaku klasycznego i słabą konwertazy C3 szlaku alternatywnego.
- Dlatego też mysi Crry/p65 wykorzystuje specyficzne mechanizmy zarówno ludzkiego MCP, jak i DAF. Chociaż Crry/p65, podobnie jak MCP i DAF, zawiera tandemowe krótkie konsensusowe powtórzenia (SCR) charakterystyczne dla białek wiążących C3/C4 , Crry/p65 nie jest uważany za genetyczny homolog ani MCP, ani DAF.
- Tak więc Crry/p65 jest przykładem konserwowania ewolucyjnego dwóch specyficznych aktywności w jednym unikalnym białku u jednego gatunku, które są rozproszone w poszczególnych białkach w innym.
C4b Binding Protein |
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| A109 | Complement Technology | 250 µg/vial | 288 EUR |
Goat Anti-Human C4b Binding Protein |
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| A209 | Complement Technology | 1 ml/vial | 166 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6249778-01mL | MyBiosource | 0.1(mL | 1130 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6249778-5x01mL | MyBiosource | 5x0.1mL | 4925 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6250770-01mL | MyBiosource | 0.1(mL | 1130 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6250770-5x01mL | MyBiosource | 5x0.1mL | 4925 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6252736-01mL | MyBiosource | 0.1(mL | 1130 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6252736-5x01mL | MyBiosource | 5x0.1mL | 4925 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6254816-01mL | MyBiosource | 0.1(mL | 1130 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6254816-5x01mL | MyBiosource | 5x0.1mL | 4925 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6248849-01mL | MyBiosource | 0.1(mL | 1130 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6248849-5x01mL | MyBiosource | 5x0.1mL | 4925 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6251725-01mL | MyBiosource | 0.1(mL | 1130 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6251725-5x01mL | MyBiosource | 5x0.1mL | 4925 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6247828-01mL | MyBiosource | 0.1(mL | 1130 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6247828-5x01mL | MyBiosource | 5x0.1mL | 4925 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6253776-01mL | MyBiosource | 0.1(mL | 1130 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6253776-5x01mL | MyBiosource | 5x0.1mL | 4925 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6255856-01mL | MyBiosource | 0.1(mL | 1130 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6255856-5x01mL | MyBiosource | 5x0.1mL | 4925 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6268682-01mL | MyBiosource | 0.1mL | 1130 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6268682-5x01mL | MyBiosource | 5x0.1mL | 4925 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6256895-01mL | MyBiosource | 0.1mL | 1130 EUR |
Complement Component 4 Binding Protein (C4 Binding Protein, C4BP, Complement Component 4 Binding Protein alpha Chain, C4b Binding Protein alpha Chain, C4BPA, Complement Component 4 Binding Protein beta Chain, C4b Binding Protein beta Chain, C4BPB, Proline |
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| MBS6256895-5x01mL | MyBiosource | 5x0.1mL | 4925 EUR |
Human Complement Component 4 Binding Protein (C4BP) ELISA Kit |
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| abx052696-96tests | Abbexa | 96 tests | 943.2 EUR |
Human Complement Component 4 Binding Protein |
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| MBS147430-002mg | MyBiosource | 0.02mg | 380 EUR |
Human Complement Component 4 Binding Protein |
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| MBS147430-01mg | MyBiosource | 0.1mg | 825 EUR |
Human Complement Component 4 Binding Protein |
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| MBS147430-1mg | MyBiosource | 1mg | 3670 EUR |
Human Complement Component 4 Binding Protein |
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| MBS147430-5x1mg | MyBiosource | 5x1mg | 16190 EUR |
Human Complement C1q Binding Protein (C1QBP) Protein |
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| abx067141-100g | Abbexa | 100 µg | 512.5 EUR |
Human Complement C1q Binding Protein (C1QBP) Protein |
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| abx067141-10g | Abbexa | 10 µg | 212.5 EUR |
Human Complement C1q Binding Protein (C1QBP) Protein |
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| abx067141-50g | Abbexa | 50 µg | 362.5 EUR |
Recombinant Monkeypox Virus D15L Protein, Secreted complement binding C3b-C4b |
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| MPXV-0400 | Creative BioMart | 100ug | 3198.4 EUR |
C4BPA (untagged)-Human complement component 4 binding protein, alpha (C4BPA) |
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| SC119723 | Origene Technologies GmbH | 10 µg | Ask for price |
Human Complement Component 4 Binding Protein Alpha (C4BPA) ELISA Kit |
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| abx573776-96tests | Abbexa | 96 tests | 943.2 EUR |
C4BPA (GFP-tagged) - Human complement component 4 binding protein, alpha (C4BPA) |
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| RG204738 | Origene Technologies GmbH | 10 µg | Ask for price |
Human Complement C1q Binding Protein (C1QBP) CLIA Kit |
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| abx195279-96tests | Abbexa | 96 tests | 618.75 EUR |
Human Complement C1q Binding Protein (C1QBP) CLIA Kit |
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| 20-abx491829 | Abbexa |
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Human Complement C1q Binding Protein (C1QBP) ELISA Kit |
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| abx250324-96tests | Abbexa | 96 tests | 562.5 EUR |
C4BPA (Myc-DDK-tagged)-Human complement component 4 binding protein, alpha (C4BPA) |
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| RC204738 | Origene Technologies GmbH | 10 µg | Ask for price |
Recombinant Human Complement Component 4 Binding Protein, Beta |
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| MBS144974-0005mg | MyBiosource | 0.005mg | 240 EUR |
Recombinant Human Complement Component 4 Binding Protein, Beta |
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| MBS144974-0025mg | MyBiosource | 0.025mg | 310 EUR |
Recombinant Human Complement Component 4 Binding Protein, Beta |
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| MBS144974-1mg | MyBiosource | 1mg | 2880 EUR |
Recombinant Human Complement Component 4 Binding Protein, Beta |
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| MBS144974-5x1mg | MyBiosource | 5x1mg | 12630 EUR |
Recombinant Human Complement Component 4 Binding Protein, beta |
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| MBS556325-0005mg | MyBiosource | 0.005mg | 220 EUR |
Recombinant Human Complement Component 4 Binding Protein, beta |
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| MBS556325-0025mg | MyBiosource | 0.025mg | 320 EUR |
Recombinant Human Complement Component 4 Binding Protein, beta |
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| MBS556325-5x0025mg | MyBiosource | 5x0.025mg | 1300 EUR |
Complement Component 4 Binding Protein, Beta Human Recombinant |
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| rAP-3065 | Angio Proteomie | Inquiry | Ask for price |
C4BPB (untagged)-Human complement component 4 binding protein, beta (C4BPB), transcript variant 1 |
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| SC125997 | Origene Technologies GmbH | 10 µg | Ask for price |
C4BPB (untagged)-Human complement component 4 binding protein, beta (C4BPB), transcript variant 2 |
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| SC302017 | Origene Technologies GmbH | 10 µg | Ask for price |
C4BPB (untagged)-Human complement component 4 binding protein, beta (C4BPB), transcript variant 4 |
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| SC302019 | Origene Technologies GmbH | 10 µg | Ask for price |
C4BPB (untagged)-Human complement component 4 binding protein, beta (C4BPB), transcript variant 5 |
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| SC302020 | Origene Technologies GmbH | 10 µg | Ask for price |
C4BPB (untagged)-Human complement component 4 binding protein, beta (C4BPB), transcript variant 3 |
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| SC319699 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Human complement component 4 binding protein, alpha (C4BPA), mGFP tagged |
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| RC204738L4 | Origene Technologies GmbH | 10 µg | Ask for price |
Complement Component 4 Binding Protein Beta (C4BPB) Antibody |
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| 20-abx004862 | Abbexa |
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Complement Component 4 Binding Protein Beta (C4BPB) Antibody |
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| abx028563-400ul | Abbexa | 400 ul | 627.6 EUR |
Complement Component 4 Binding Protein Beta (C4BPB) Antibody |
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| 20-abx322341 | Abbexa |
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Complement Component 4 Binding Protein Beta (C4BPB) Antibody |
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| abx231114-100ug | Abbexa | 100 ug | 577.2 EUR |
Complement Component 4 Binding Protein Beta (C4BPB) Antibody |
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| 20-abx320333 | Abbexa |
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Human Complement Component 4b (C4b) Protein |
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| 20-abx166851 | Abbexa |
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Complement Component 4 Binding Protein Alpha (C4BPA) Antibody |
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| abx032673-400ul | Abbexa | 400 ul | 627.6 EUR |
Complement Component 4 Binding Protein Alpha (C4BPA) Antibody |
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| 20-abx006497 | Abbexa |
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Complement Component 4 Binding Protein Alpha (C4BPA) Antibody |
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| 20-abx301144 | Abbexa |
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Complement Component 4 Binding Protein Alpha (C4BPA) Antibody |
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| abx231113-100ug | Abbexa | 100 ug | 577.2 EUR |
C4BPB (GFP-tagged) - Human complement component 4 binding protein, beta (C4BPB), transcript variant 2 |
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| RG219158 | Origene Technologies GmbH | 10 µg | Ask for price |
C4BPB (GFP-tagged) - Human complement component 4 binding protein, beta (C4BPB), transcript variant 5 |
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| RG219216 | Origene Technologies GmbH | 10 µg | Ask for price |
C4BPB (GFP-tagged) - Human complement component 4 binding protein, beta (C4BPB), transcript variant 3 |
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| RG202799 | Origene Technologies GmbH | 10 µg | Ask for price |
C4BPB (GFP-tagged) - Human complement component 4 binding protein, beta (C4BPB), transcript variant 4 |
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| RG222050 | Origene Technologies GmbH | 10 µg | Ask for price |
C4BPB (GFP-tagged) - Human complement component 4 binding protein, beta (C4BPB), transcript variant 1 |
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| RG223685 | Origene Technologies GmbH | 10 µg | Ask for price |
C4bp (GFP-tagged) - Mouse complement component 4 binding protein (C4bp) |
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| MG206786 | Origene Technologies GmbH | 10 µg | Ask for price |
Complement Component 4 Binding Protein, beta |
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| PR27270 | Neuromics | 5 ug | 97.2 EUR |
Complement Component 4 Binding Protein, beta |
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| PR27270-B | Neuromics | each | 184.5 EUR |
Cow Complement C1q Binding Protein (C1QBP) Protein |
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| abx165992-100g | Abbexa | 100 µg | 750 EUR |
Cow Complement C1q Binding Protein (C1QBP) Protein |
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| abx165992-10g | Abbexa | 10 µg | 425 EUR |
Cow Complement C1q Binding Protein (C1QBP) Protein |
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| abx165992-50g | Abbexa | 50 µg | 612.5 EUR |
Rat Complement C1q Binding Protein (C1QBP) Protein |
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| abx067143-100g | Abbexa | 100 µg | 550 EUR |
Rat Complement C1q Binding Protein (C1QBP) Protein |
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| abx067143-10g | Abbexa | 10 µg | 212.5 EUR |
Rat Complement C1q Binding Protein (C1QBP) Protein |
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| abx067143-50g | Abbexa | 50 µg | 387.5 EUR |
C4bp (untagged) - Mouse complement component 4 binding protein (C4bp), (10ug) |
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| MC205732 | Origene Technologies GmbH | 10 µg | Ask for price |
Complement Component 4 Binding Protein Alpha (C4BPA) Antibody (HRP) |
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| 20-abx303257 | Abbexa |
|
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C4BPB (Myc-DDK-tagged)-Human complement component 4 binding protein, beta (C4BPB), transcript variant 2 |
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| RC219158 | Origene Technologies GmbH | 10 µg | Ask for price |
C4BPB (Myc-DDK-tagged)-Human complement component 4 binding protein, beta (C4BPB), transcript variant 5 |
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| RC219216 | Origene Technologies GmbH | 10 µg | Ask for price |
C4BPB (Myc-DDK-tagged)-Human complement component 4 binding protein, beta (C4BPB), transcript variant 1 |
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| RC223685 | Origene Technologies GmbH | 10 µg | Ask for price |
C4BPB (Myc-DDK-tagged)-Human complement component 4 binding protein, beta (C4BPB), transcript variant 4 |
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| RC222050 | Origene Technologies GmbH | 10 µg | Ask for price |
C4BPB (Myc-DDK-tagged)-Human complement component 4 binding protein, beta (C4BPB), transcript variant 3 |
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| RC202799 | Origene Technologies GmbH | 10 µg | Ask for price |
Human Complement C4b |
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| MBS147386-002mg | MyBiosource | 0.02mg | 380 EUR |
Human Complement C4b |
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| MBS147386-01mg | MyBiosource | 0.1mg | 825 EUR |
Human Complement C4b |
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| MBS147386-1mg | MyBiosource | 1mg | 3670 EUR |
Human Complement C4b |
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| MBS147386-5x1mg | MyBiosource | 5x1mg | 16190 EUR |
Lenti ORF clone of Human complement component 4 binding protein, alpha (C4BPA), Myc-DDK-tagged |
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| RC204738L3 | Origene Technologies GmbH | 10 µg | Ask for price |
Complement Component 4 Binding Protein, beta Protein |
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| abx260927-10g | Abbexa | 10 µg | 325 EUR |
Complement Component 4 Binding Protein, beta Protein |
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| 20-abx260927 | Abbexa |
|
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Complement Component 4 Binding Protein, beta Protein |
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| abx260927-2g | Abbexa | 2 µg | 225 EUR |
Complement Component 4 Binding Protein Alpha (C4BPA) Antibody (FITC) |
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| 20-abx303258 | Abbexa |
|
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Mouse Complement C1q Binding Protein (C1QBP) Protein |
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| abx067142-100g | Abbexa | 100 µg | 550 EUR |
Mouse Complement C1q Binding Protein (C1QBP) Protein |
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| abx067142-10g | Abbexa | 10 µg | 212.5 EUR |
Mouse Complement C1q Binding Protein (C1QBP) Protein |
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| abx067142-50g | Abbexa | 50 µg | 387.5 EUR |
Complement Component 4 Binding Protein Alpha (C4BPA) Antibody (Biotin) |
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| 20-abx303259 | Abbexa |
|
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Complement C1q Binding Protein (C1QBP) Antibody |
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| abx001547-100l | Abbexa | 100 µl | 400 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
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| 20-abx001547 | Abbexa |
|
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Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx001547-20l | Abbexa | 20 µl | 175 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx001547-50l | Abbexa | 50 µl | 275 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx033710-100g | Abbexa | 100 µg | 281.25 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx033711-100g | Abbexa | 100 µg | 250 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx033711-400ul | Abbexa | 400 ul | 627.6 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx033711-80l | Abbexa | 80 µl | 343.2 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx014385-100g | Abbexa | 100 µg | 43.75 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
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| 20-abx014385 | Abbexa |
|
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Complement C1q Binding Protein (C1QBP) Antibody |
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| 20-abx009533 | Abbexa |
|
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Complement C1q Binding Protein (C1QBP) Antibody |
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| abx103015-100l | Abbexa | 100 µl | 250 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
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| abx103015-1ml | Abbexa | 1 ml | 675 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
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| abx103015-200l | Abbexa | 200 µl | 312.5 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx103016-100l | Abbexa | 100 µl | 262.5 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx103016-1ml | Abbexa | 1 ml | 687.5 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx103016-200l | Abbexa | 200 µl | 325 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx103017-100l | Abbexa | 100 µl | 262.5 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
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| abx103017-1ml | Abbexa | 1 ml | 725 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx103017-200l | Abbexa | 200 µl | 337.5 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
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| abx330600-100ul | Abbexa | 100 ul | 510 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
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| abx137570-01mg | Abbexa | 0.1 mg | 225 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
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| abx172843-100l | Abbexa | 100 µl | 262.5 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx172843-1ml | Abbexa | 1 ml | 712.5 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx172843-200l | Abbexa | 200 µl | 325 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx270253-1ml | Abbexa | 1 ml | 387.5 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx270253-200l | Abbexa | 200 µl | 275 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx231073-100g | Abbexa | 100 µg | 350 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx231073-100ug | Abbexa | 100 ug | 577.2 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx104799-100g | Abbexa | 100 µg | 812.5 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
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| abx104799-20g | Abbexa | 20 µg | 287.5 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
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| abx104799-50g | Abbexa | 50 µg | 362.5 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
|||
| abx328821-100l | Abbexa | 100 µl | 187.5 EUR |
Complement C1q Binding Protein (C1QBP) Antibody |
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| 20-abx328821 | Abbexa |
|
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Mouse Complement Fragment C4b (C4b) Protein |
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| abx066058-100g | Abbexa | 100 µg | 475 EUR |
Mouse Complement Fragment C4b (C4b) Protein |
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| abx066058-10g | Abbexa | 10 µg | 200 EUR |
Mouse Complement Fragment C4b (C4b) Protein |
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| abx066058-50g | Abbexa | 50 µg | 337.5 EUR |
C4bp (Myc-DDK-tagged) - Mouse complement component 4 binding protein (C4bp) |
|||
| MR206786 | Origene Technologies GmbH | 10 µg | Ask for price |
C4bpb (untagged ORF) - Rat complement component 4 binding protein, beta (C4bpb), (10 ug) |
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| RN207679 | Origene Technologies GmbH | 10 µg | Ask for price |
Complement C1q Binding Protein (C1QBP) Antibody (FITC) |
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| abx273770-25mg | Abbexa | 25 mg | 950 EUR |
Complement C1q Binding Protein (C1QBP) Antibody (FITC) |
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| abx273770-5mg | Abbexa | 5 mg | 400 EUR |
Complement C1q Binding Protein (C1QBP) Antibody (FITC) |
|||
| abx273986-10mg | Abbexa | 10 mg | 412.5 EUR |
Complement C1q Binding Protein (C1QBP) Antibody (FITC) |
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| abx273986-50mg | Abbexa | 50 mg | 975 EUR |
Complement C1q Binding Protein (C1QBP) Antibody (FITC) |
|||
| abx274123-05ml | Abbexa | 0.5 ml | 425 EUR |
Lenti ORF particles, C4BPA (mGFP-tagged) - Human complement component 4 binding protein, alpha (C4BPA), 200ul, >10^7 TU/mL |
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| RC204738L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Rat Complement C1q Binding Protein (C1QBP) CLIA Kit |
|||
| abx195278-96tests | Abbexa | 96 tests | 618.75 EUR |
CD35 (C3 binding Protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen, CR1) (AP) |
|||
| MBS6123946-01mL | MyBiosource | 0.1(mL | 935 EUR |
CD35 (C3 binding Protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen, CR1) (AP) |
|||
| MBS6123946-5x01mL | MyBiosource | 5x0.1mL | 4050 EUR |
CD35 (C3 binding Protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen, CR1) (APC) |
|||
| MBS6123947-01mL | MyBiosource | 0.1(mL | 935 EUR |
CD35 (C3 binding Protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen, CR1) (APC) |
|||
| MBS6123947-5x01mL | MyBiosource | 5x0.1mL | 4050 EUR |
CD35 (C3 binding Protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen, CR1) (Biotin) |
|||
| MBS6123948-01mL | MyBiosource | 0.1(mL | 935 EUR |
CD35 (C3 binding Protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen, CR1) (Biotin) |
|||
| MBS6123948-5x01mL | MyBiosource | 5x0.1mL | 4050 EUR |
CD35 (C3 binding Protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen, CR1) (FITC) |
|||
| MBS6123949-01mL | MyBiosource | 0.1(mL | 935 EUR |
CD35 (C3 binding Protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen, CR1) (FITC) |
|||
| MBS6123949-5x01mL | MyBiosource | 5x0.1mL | 4050 EUR |
CD35 (C3 binding Protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen, CR1) (HRP) |
|||
| MBS6123950-01mL | MyBiosource | 0.1(mL | 935 EUR |
CD35 (C3 binding Protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen, CR1) (HRP) |
|||
| MBS6123950-5x01mL | MyBiosource | 5x0.1mL | 4050 EUR |
CD35 (C3 binding Protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen, CR1) (PE) |
|||
| MBS6123951-01mL | MyBiosource | 0.1(mL | 935 EUR |
CD35 (C3 binding Protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen, CR1) (PE) |
|||
| MBS6123951-5x01mL | MyBiosource | 5x0.1mL | 4050 EUR |
CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (AP) |
|||
| MBS6122153-01mL | MyBiosource | 0.1(mL | 935 EUR |
CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (AP) |
|||
| MBS6122153-5x01mL | MyBiosource | 5x0.1mL | 4050 EUR |
CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (APC) |
|||
| MBS6122154-01mL | MyBiosource | 0.1(mL | 935 EUR |
CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (APC) |
|||
| MBS6122154-5x01mL | MyBiosource | 5x0.1mL | 4050 EUR |
CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (Biotin) |
|||
| MBS6122155-01mL | MyBiosource | 0.1(mL | 935 EUR |
CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (Biotin) |
|||
| MBS6122155-5x01mL | MyBiosource | 5x0.1mL | 4050 EUR |
CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (FITC) |
|||
| MBS6122156-01mL | MyBiosource | 0.1(mL | 935 EUR |
CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (FITC) |
|||
| MBS6122156-5x01mL | MyBiosource | 5x0.1mL | 4050 EUR |
CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (HRP) |
|||
| MBS6122157-01mL | MyBiosource | 0.1(mL | 935 EUR |
CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (HRP) |
|||
| MBS6122157-5x01mL | MyBiosource | 5x0.1mL | 4050 EUR |
CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (PE) |
|||
| MBS6122158-01mL | MyBiosource | 0.1(mL | 935 EUR |
CD35 (CR1, C3 binding protein, C3b/C4b receptor, C3BR, C4BR, Complement Component (3b/4b) receptor 1 including Knops blood group system, Complement receptor type 1, KN, Knops blood group antigen) (PE) |
|||
| MBS6122158-5x01mL | MyBiosource | 5x0.1mL | 4050 EUR |
Rat Complement C1q Binding Protein (C1QBP) ELISA Kit |
|||
| abx255702-1096tests | Abbexa | 10 × 96 tests | Ask for price |
Rat Complement C1q Binding Protein (C1QBP) ELISA Kit |
|||
| abx255702-596tests | Abbexa | 5 × 96 tests | Ask for price |
Rat Complement C1q Binding Protein (C1QBP) ELISA Kit |
|||
| abx255702-96tests | Abbexa | 96 tests | 562.5 EUR |
C4bpa (untagged ORF) - Rat complement component 4 binding protein, alpha (C4bpa), (10 ug) |
|||
| RN200781 | Origene Technologies GmbH | 10 µg | Ask for price |
Recombinant Human Complement C4B Protein-GST tag |
|||
| CTP-061 | Creative Biolabs | 100ug | Ask for price |
Recombinant Human Complement C4B Protein-His tag |
|||
| CTP-062 | Creative Biolabs | 100ug | Ask for price |
Complement C1q Binding Protein (C1QBP) Antibody (Biotin) |
|||
| abx272022-1ml | Abbexa | 1 ml | 737.5 EUR |
Complement C1q Binding Protein (C1QBP) Antibody (Biotin) |
|||
| abx272022-200l | Abbexa | 200 µl | 337.5 EUR |
Complement C1q Binding Protein (C1QBP) Antibody (Biotin) |
|||
| abx272724-100l | Abbexa | 100 µl | 375 EUR |
Complement C1q Binding Protein (C1QBP) Antibody (Biotin) |
|||
| abx272724-1ml | Abbexa | 1 ml | Ask for price |
Complement C1q Binding Protein (C1QBP) Antibody (Biotin) |
|||
| abx272724-200l | Abbexa | 200 µl | 850 EUR |
Complement C1q Binding Protein (C1QBP) Antibody (Biotin) |
|||
| 20-abx273199 | Abbexa |
|
|
Complement C1q Binding Protein (C1QBP) Antibody (Biotin) |
|||
| abx273199-5mg | Abbexa | 5 mg | 800 EUR |
Lenti ORF particles, C4BPA (Myc-DDK tagged) - Human complement component 4 binding protein, alpha (C4BPA), 200ul, >10^7 TU/mL |
|||
| RC204738L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Proponujemy, że powtarzający się motyw SCR w tej rodzinie umożliwił zajście tego niezwykłego procesu ewolucji, być może napędzanego przez użycie MCP i DAF jako receptorów przez ludzkie patogeny, takie jak wirus odry.
