Endemic species having an area distribution within the southwestern coastal district of Turkey. Styrax liquidus gum (SLG), is a gum-like resinous which exudates in response to harm of the trunk of LOM. The purpose of the research was to analyze the cytotoxic results and the molecular mechanisms of the ethanolic SLG extract in human prostate most cancers cells. GC-MS evaluation was carried out to establish the risky compound composition. Cytotoxicity was decided by XTT evaluation.

Apoptosis and necrosis have been evaluated by way of ELISA assay. Autophagic cell loss of life was detected by way of monodansylcadaverine (MDC) staining and by measuring the degrees of LC3I and LC3II. The protein ranges of p-PI3K, p-Akt and p-mTOR have been evaluated by western blot evaluation.

Within the current research, it’s proven that the SLG extract containing a substantial quantity of ravidomycin derivate induced autophagic cell loss of life in prostate most cancers cells by way of inhibiting the PI3K/Akt/mTOR pathway.

Osteopontin Regulates Endometrial Stromal Cell Migration in Endometriosis by the PI3K Pathway : Osteopontin Regulates Endometrial Cell Migration in Endometriosis

Endometriosis is usually characterised as a tumor-like illness due to its potential for distant metastasis and native tissue invasion, whereas whether or not osteopontin (OPN) performs a job within the pathogenesis of endometriosis has not been completely investigated.

We investigated the expression of OPN, urokinase plasminogen activator (uPA), phosphatidylinositol three kinase (PI3K), and phospho-PI3 kinase (p-PI3K) in endometrial stromal cells (ESCs). The serum focus of OPN was decided by enzyme-linked immunosorbent assays (ELISA). OPN was downregulated to discover the corresponding change of uPA, p-PI3K, F-actin, and α-tubulin.

The expression of OPN, uPA, PI3K, and p-PI3K was evaluated by western blot and quantitative real-time PCR (RT-qPCR) and the expression of F-actin and α-tubulin was confirmed by immunofluorescence assay.

Human Cancer PrimaCell6: Colorectal Tumor Cells
2-96029 1 Kit Ask for price

Human Cancer PrimaCell9: Kidney Tumor Cells
2-96032 1 Kit Ask for price

Human Cancer PrimaCell10: Liver Tumor Cells
2-96033 1 Kit Ask for price

Human Cancer PrimaCell11: Lung Tumor Cells
2-96034 1 Kit Ask for price

Human Cancer PrimaCell12: Ovarian Tumor Cells
2-96035 1 Kit Ask for price

Human Cancer PrimaCell13: Pancreatic Tumor Cells
2-96036 1 Kit Ask for price

Human Cancer PrimaCell14: Rectal Tumor Cells
2-96037 1 Kit Ask for price

Human Cancer PrimaCell16: Stomach Tumor Cells
2-96039 1 Kit Ask for price

Human Cancer PrimaCell18: Thyroid Carcinoma Cells
2-96041 1 Kit Ask for price

Human Cancer PrimaCell19: Uterine Tumor Cells
2-96042 1 Kit Ask for price

Autobioluminescent Human Colorectal Cancer Cells (HCT116)
ASE-5901 1 ml
EUR 2976
Description: 6 month

Autobioluminescent Human Breast Cancer Cells (MCF7)
ASE-5903 1 ml
EUR 2490
Description: 6 month

Autobioluminescent Human Breast Cancer Cells (T47D)
ASE-5904 1 ml
EUR 2490
Description: 6 month

Human Cancer PrimaCell2: Biliary Tract Tumor Cells
2-96025 1 Kit Ask for price

Human Cancer PrimaCell8: Glioma Cells Growth Medium
9-46031 5 x 100 ml Ask for price

Human Cancer PrimaCell1: Esophageal Tumor Cells Growth Medium
9-46024 5 x 100 ml Ask for price

Human Cancer PrimaCell3: Bladder Tumor Cells Growth Medium
9-46026 5 x 100 ml Ask for price

Human Cancer PrimaCell4: Breast Tumor Cells Growth Medium
9-46027 5 x 100 ml Ask for price

Human Cancer PrimaCell5: Cervical Tumor Cells Growth Medium
9-46028 5 x 100 ml Ask for price

Human Cancer PrimaCell6: Colorectal Tumor Cells Growth Medium
9-46029 5 x 100 ml Ask for price

Human Cancer PrimaCell9: Kidney Tumor Cells Growth Medium
9-46032 5 x 100 ml Ask for price

Human Cancer PrimaCell10: Liver Tumor Cells Growth Medium
9-46033 5 x 100 ml Ask for price

Human Cancer PrimaCell11: Lung Tumor Cells Growth Medium
9-46034 5 x 100 ml Ask for price

Human Cancer PrimaCell12: Ovarian Tumor Cells Growth Medium
9-46035 5 x 100 ml Ask for price

Human Cancer PrimaCell13: Pancreatic Tumor Cells Growth Medium
9-46036 5 x 100 ml Ask for price

Human Cancer PrimaCell14: Rectal Tumor Cells Growth Medium
9-46037 5 x 100 ml Ask for price

Human Cancer PrimaCell16: Stomach Tumor Cells Growth Medium
9-46039 5 x 100 ml Ask for price

Human Cancer PrimaCell18: Thyroid Carcinoma Cells Growth Medium
9-46041 5 x 100 ml Ask for price

Human Cancer PrimaCell19: Uterine Tumor Cells Growth Medium
9-46042 5 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 8: Glioma Cells
9-80031 1 x 100 ml Ask for price

Human Cancer PrimaCell2: Biliary Tract Tumor Cells Growth Medium
9-46025 5 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 1: Esophageal Tumor Cells
9-80024 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 3: Bladder Tumor Cells
9-80026 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 4: Breast Tumor Cells
9-80027 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 5: Cervical Tumor Cells
9-80028 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 6: Colorectal Tumor Cells
9-80029 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 9: Kidney Tumor Cells
9-80032 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 10: Liver Tumor Cells
9-80033 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 11: Lung Tumor Cells
9-80034 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 12: Ovarian Tumor Cells
9-80035 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 13: Pancreatic Tumor Cells
9-80036 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 14: Rectal Tumor Cells
9-80037 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 16: Stomach Tumor Cells
9-80039 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 18: Thyroid Carcinoma Cells
9-80041 1 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 19: Uterine Tumor Cells
9-80042 1 x 100 ml Ask for price

Breast Cancer Cells (a-peptide 18), Peptide Aptamer, Biotinylated
AP-305-B 1 mg Ask for price

Breast Cancer Cells (a-peptide 18), Peptide Aptamer, unlabeled
AP-305-U 5 mg Ask for price

Human Cancer PrimaCell15: Skin Cancer Cells Growth Supplements with Serum (for 500 ml medium)
9-47038 1 Set Ask for price

Human Receptor-binding cancer antigen expressed on SiSo cells (EBAG9)
1-CSB-EP007355HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Receptor-binding cancer antigen expressed on SiSo cells(EBAG9),partial expressed in E.coli

Receptor-Binding Cancer Antigen Expressed On SiSo Cells (EBAG9) Antibody
20-abx123391
  • EUR 493.20
  • EUR 710.40
  • 100 ul
  • 200 ul

Receptor-Binding Cancer Antigen Expressed On SiSo Cells (EBAG9) Antibody
20-abx112338
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Receptor-Binding Cancer Antigen Expressed On SiSo Cells (EBAG9) Antibody
20-abx001581
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Receptor-Binding Cancer Antigen Expressed On SiSo Cells (EBAG9) Antibody
abx037831-100ug 100 ug
EUR 469.2

Receptor-Binding Cancer Antigen Expressed On SiSo Cells (EBAG9) Antibody
abx037482-100ug 100 ug
EUR 469.2

Receptor-Binding Cancer Antigen Expressed On SiSo Cells (EBAG9) Antibody
abx031290-400ul 400 ul
EUR 627.6

Receptor-Binding Cancer Antigen Expressed On SiSo Cells (EBAG9) Antibody
abx031290-80l 80 µl
EUR 343.2

Receptor-Binding Cancer Antigen Expressed On SiSo Cells (EBAG9) Antibody
abx430429-200ul 200 ul
EUR 460.8

Leucine Zipper Protein Down-Regulated In Cancer Cells (LDOC1) Antibody
abx234744-100ug 100 ug
EUR 610.8

Human Cancer Tissue Preparation Buffer 2: Biliary Tract Tumor Cells
9-80025 1 x 100 ml Ask for price

Breast Cancer Cells (a-peptide 18), Peptide Aptamer, FITC labelled
AP-305-F 1 mg Ask for price

PC-3 Human prostate cancer cells derived from metastatic cancer cell line: >1x10^10 frozen exosomes
EXOP-115A-1 50 ug
EUR 560.4

Leucine Zipper Protein Down-Regulated In Cancer Cells-Like (LDOC1L) Antibody
20-abx013659
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Leucine Zipper Protein Down-Regulated In Cancer Cells-Like (LDOC1L) Antibody
abx030424-400ul 400 ul
EUR 627.6

Leucine Zipper Protein Down-Regulated In Cancer Cells-Like (LDOC1L) Antibody
abx030424-80l 80 µl
EUR 343.2

Human EBAG9/ Receptor-binding cancer antigen expressed on SiSo cells ELISA Kit
E0748Hu 1 Kit
EUR 685.2

Dog Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) ELISA Kit
abx512994-96tests 96 tests
EUR 1093.2

Human Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) ELISA Kit
abx512995-96tests 96 tests
EUR 801.6

Mouse Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) ELISA Kit
abx512996-96tests 96 tests
EUR 801.6

Rat Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) ELISA Kit
abx512997-96tests 96 tests
EUR 801.6

Human Leucine Zipper Protein Down-Regulated In Cancer Cells (LDOC1) ELISA Kit
abx388251-96tests 96 tests
EUR 1093.2

Human receptor-binding cancer antigen expressed on SiSo cells?RCAS1 ELISA kit
201-12-2019 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human receptor-binding cancer antigen expressed on SiSo cells(RCAS1)ELISA Kit
QY-E04136 96T
EUR 472.8

Human receptor-binding cancer antigen expressed on SiSo cells(RCAS1) ELISA kit
YLA2885HU-48T 48T
EUR 435

Human receptor-binding cancer antigen expressed on SiSo cells(RCAS1) ELISA kit
YLA2885HU-96T 96T
EUR 562.5

Dendritic Cells/B Cells Antibody
abx412775-02mg 0.2 mg
EUR 678

anti-CD45 RA B-cells, T-cells, NK-cells
516-A-01mg 0,1 mg
EUR 321
Description: anti-CD45 RA B-cells, T-cells, NK-cells

anti-CD45 RA B-cells, T-cells, NK-cells
516-A-1000ug 1000 ug
EUR 1539
Description: anti-CD45 RA B-cells, T-cells, NK-cells

Human Cancer PrimaCell8: Glioma Cells Growth Supplements with Serum (for 500 ml medium)
9-47031 1 Set Ask for price

Liver cancer
BC03117 each
EUR 306
Description: Liver cancer, liver cirrhosis tissue array with normal tissue as control, including TNM, clinical stage, pathology grade and history of hepatitis, 70 cases/ 80 cores, replaced by BC03117a

Breast cancer
BR1008b each
EUR 306
Description: Breast cancer, lymph node metastatic carcinoma and adjacent normal tissue array, including pathology grade, TNM, clinical stage, and ER/PR/Her2 result, 100 cases/100 cores, replacing BR1008a

Breast cancer
BR724 each
EUR 270
Description: Breast cancer, adjacent and adjacent normal tissue array, 66 cases/72 cores

Breast cancer
BR725 each
EUR 270
Description: Breast cancer, adjacent and adjacent normal tissue array, 68 cases/72 cores

Colorectal cancer
CRM1501 each
EUR 420
Description: Colorectal cancer, 150 cases.

Esophagus cancer
ES1041 each
EUR 306
Description: Esophagus cancer, cancer adjacent and normal esophagus tissue array, including squamous cell carcinoma,adenocarcinoma,undifferentiated carcinoma, AT and normal tissue, pathology grade, TNM and clinical stage (AJCC 8.0), 104 cases/104 cores (core size 1.5mm), replacing ES1021

Lung cancer
LC751 each
EUR 234
Description: Lung cancer, matched cancer adjacent and normal adjacent lung tissue array, including pathology grade, TNM and clinical stage (AJCC 8.0), 25 cases/75 cores (core size 1.5mm),Recent Year Collection

Prostate cancer
PR632 each
EUR 306
Description: Prostate cancer, hyperplasia with normal tissue array, including pathology grade, Gleason grade, Gleason score, TNM and clinical stage, 21cases/63 cores

Stomach cancer
ST1451a each
EUR 540
Description: Stomach cancer, matched NAT, matched metastasis tissue (recent year collection samples), including pathology grade, TNM and clinical stage, 71 cases/145 cores, replacing ST1451

5637 cells
C0002001 One Frozen vial
EUR 582

MB49 cells
C0002004 One Frozen vial
EUR 932.4

K562 cells
C0003004 One Frozen vial
EUR 546

U937 cells
C0003005 One Frozen vial
EUR 546

Raji cells
C0003009 One Frozen vial
EUR 546

Daudi cells
C0003010 One Frozen vial
EUR 546

RS4;11 cells
C0003012 One Frozen vial
EUR 546

NAMALWA cells
C0003013 One Frozen vial
EUR 546

BJAB cells
C0003016 One Frozen vial
EUR 651.6

FO cells
C0003017 One Frozen vial
EUR 582

MC116 cells
C0003021 One Frozen vial
EUR 582

P3X63Ag8.653 cells
C0003028 One Frozen vial
EUR 546

REH cells
C0003031 One Frozen vial
EUR 582

Mino cells
C0003033 One Frozen vial
EUR 582

U87MG cells
C0005002 One Frozen vial
EUR 546

B103 cells
C0005003 One Frozen vial
EUR 932.4

T47D cells
C0006001 One Frozen vial
EUR 546

4T1 cells
C0006004 One Frozen vial
EUR 546

HeLa cells
C0008001 One Frozen vial
EUR 546

SiHa cells
C0008002 One Frozen vial
EUR 546

C33A cells
C0008003 One Frozen vial
EUR 546

CaSKi cells
C0008004 One Frozen vial
EUR 546

SW480 cells
C0009001 One Frozen vial
EUR 546

SW620 cells
C0009002 One Frozen vial
EUR 546

T84 cells
C0009008 One Frozen vial
EUR 546

HCT15 cells
C0009010 One Frozen vial
EUR 546

LoVo cells
C0009011 One Frozen vial
EUR 546

RKO cells
C0009012 One Frozen vial
EUR 546

SW48 cells
C0009014 One Frozen vial
EUR 546

SW1116 cells
C0009019 One Frozen vial
EUR 546

H716 cells
C0009022 One Frozen vial
EUR 651.6

OE33 cells
C0013003 One Frozen vial
EUR 792

JROECL33 cells
C0013004 One Frozen vial
EUR 792

Hep3B cells
C0015001 One Frozen vial
EUR 546

HepG2 cells
C0015002 One Frozen vial
EUR 546

Calu3 cells
C0016001 One Frozen vial
EUR 546

A549 cells
C0016002 One Frozen vial
EUR 546

H460 cells
C0016003 One Frozen vial
EUR 546

A427 cells
C0016004 One Frozen vial
EUR 546

H23 cells
C0016005 One Frozen vial
EUR 546

H1703 cells
C0016008 One Frozen vial
EUR 651.6

SW1573 cells
C0016009 One Frozen vial
EUR 651.6

H520 cells
C0016010 One Frozen vial
EUR 546

H226 cells
C0016011 One Frozen vial
EUR 546

HCC4006 cells
C0016012 One Frozen vial
EUR 546

H1975 cells
C0016013 One Frozen vial
EUR 651.6

H1650 cells
C0016015 One Frozen vial
EUR 651.6

H358 cells
C0016016 One Frozen vial
EUR 546

H2228 cells
C0016017 One Frozen vial
EUR 651.6

H2170 cells
C0016018 One Frozen vial
EUR 546

H441 cells
C0016019 One Frozen vial
EUR 546

H596 cells
C0016020 One Frozen vial
EUR 546

H1581 cells
C0016028 One Frozen vial
EUR 651.6

H2444 cells
C0016038 One Frozen vial
EUR 651.6

H69AR cells
C0016046 One Frozen vial
EUR 651.6

H1373 cells
C0016047 One Frozen vial
EUR 651.6

H2122 cells
C0016048 One Frozen vial
EUR 651.6

H526 cells
C0016052 One Frozen vial
EUR 546

H1299 cells
C0016053 One Frozen vial
EUR 546

H446 cells
C0016054 One Frozen vial
EUR 651.6

H1770 cells
C0016057 One Frozen vial
EUR 651.6

H1184 cells
C0016058 One Frozen vial
EUR 651.6

H1694 cells
C0016060 One Frozen vial
EUR 651.6

The proliferation and migration skills of ESCs have been investigated by CCK8, transwell, and wound scratch assays. Endometrial OPN, p-PI3K, and uPA expressions and serum OPN ranges have been elevated in sufferers with endometriosis in contrast with the management. The expressions of p-PI3K, uPA, and α-tubulin have been decreased by siRNA-OPN interference in ectopic ESCs.

Activation and inhibition of the PI3K pathway apparently upregulate and downregulate uPA expression. Knockdown of OPN and inhibition of the PI3K pathway remarkably inhibited cell migration in ectopic ESCs.

In the meantime, activation of the PI3K pathway promoted the migration means of ectopic ESCs. OPN might regulate the expression of uPA by the PI3K sign pathway to have an effect on the migration means of ESCs, indicating that OPN, uPA, and the PI3K pathway could also be potential targets for interrupting improvement of endometriosis.