Endemic species having an area distribution within the southwestern coastal district of Turkey. Styrax liquidus gum (SLG), is a gum-like resinous which exudates in response to harm of the trunk of LOM. The purpose of the research was to analyze the cytotoxic results and the molecular mechanisms of the ethanolic SLG extract in human prostate most cancers cells. GC-MS evaluation was carried out to establish the risky compound composition. Cytotoxicity was decided by XTT evaluation.

Apoptosis and necrosis have been evaluated by way of ELISA assay. Autophagic cell loss of life was detected by way of monodansylcadaverine (MDC) staining and by measuring the degrees of LC3I and LC3II. The protein ranges of p-PI3K, p-Akt and p-mTOR have been evaluated by western blot evaluation.

Within the current research, it’s proven that the SLG extract containing a substantial quantity of ravidomycin derivate induced autophagic cell loss of life in prostate most cancers cells by way of inhibiting the PI3K/Akt/mTOR pathway.

Osteopontin Regulates Endometrial Stromal Cell Migration in Endometriosis by the PI3K Pathway : Osteopontin Regulates Endometrial Cell Migration in Endometriosis

Endometriosis is usually characterised as a tumor-like illness due to its potential for distant metastasis and native tissue invasion, whereas whether or not osteopontin (OPN) performs a job within the pathogenesis of endometriosis has not been completely investigated.

We investigated the expression of OPN, urokinase plasminogen activator (uPA), phosphatidylinositol three kinase (PI3K), and phospho-PI3 kinase (p-PI3K) in endometrial stromal cells (ESCs). The serum focus of OPN was decided by enzyme-linked immunosorbent assays (ELISA). OPN was downregulated to discover the corresponding change of uPA, p-PI3K, F-actin, and α-tubulin.

The expression of OPN, uPA, PI3K, and p-PI3K was evaluated by western blot and quantitative real-time PCR (RT-qPCR) and the expression of F-actin and α-tubulin was confirmed by immunofluorescence assay.

Human Cancer PrimaCell6: Colorectal Tumor Cells
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Human Cancer PrimaCell9: Kidney Tumor Cells
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Human Cancer PrimaCell10: Liver Tumor Cells
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Human Cancer PrimaCell11: Lung Tumor Cells
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Human Cancer PrimaCell12: Ovarian Tumor Cells
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Human Cancer PrimaCell13: Pancreatic Tumor Cells
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Autobioluminescent Human Colorectal Cancer Cells (HCT116)
ASE-5901 1 ml
EUR 2480
Description: 6 month

Autobioluminescent Human Breast Cancer Cells (MCF7)
ASE-5903 1 ml
EUR 2075
Description: 6 month

Autobioluminescent Human Breast Cancer Cells (T47D)
ASE-5904 1 ml
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Human Cancer PrimaCell8: Glioma Cells Growth Medium
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Human Cancer PrimaCell2: Biliary Tract Tumor Cells
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Breast Cancer Cells (a-peptide 18), Peptide Aptamer, Biotinylated
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Receptor-Binding Cancer Antigen Expressed On SiSo Cells (EBAG9) Antibody
20-abx112338
  • EUR 732.00
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Receptor-Binding Cancer Antigen Expressed On SiSo Cells (EBAG9) Antibody
20-abx123391
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Human Cancer Tissue Preparation Buffer 2: Biliary Tract Tumor Cells
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Receptor-Binding Cancer Antigen Expressed On SiSo Cells (EBAG9) Antibody
abx037482-100ug 100 ug
EUR 391

Receptor-Binding Cancer Antigen Expressed On SiSo Cells (EBAG9) Antibody
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EUR 391

Receptor-Binding Cancer Antigen Expressed On SiSo Cells (EBAG9) Antibody
20-abx001581
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  • EUR 314.00
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Receptor-Binding Cancer Antigen Expressed On SiSo Cells (EBAG9) Antibody
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EUR 523

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EUR 286

Receptor-Binding Cancer Antigen Expressed On SiSo Cells (EBAG9) Antibody
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Leucine Zipper Protein Down-Regulated In Cancer Cells (LDOC1) Antibody
abx234744-100ug 100 ug
EUR 509

Human Receptor-binding cancer antigen expressed on SiSo cells (EBAG9)
1-CSB-EP007355HU
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Breast Cancer Cells (a-peptide 18), Peptide Aptamer, FITC labelled
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PC-3 Human prostate cancer cells derived from metastatic cancer cell line: >1x10^10 frozen exosomes
EXOP-115A-1 50 ug
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Leucine Zipper Protein Down-Regulated In Cancer Cells-Like (LDOC1L) Antibody
20-abx013659
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abx030424-400ul 400 ul
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Leucine Zipper Protein Down-Regulated In Cancer Cells-Like (LDOC1L) Antibody
abx030424-80l 80 µl
EUR 286

Dog Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) ELISA Kit
abx512994-96tests 96 tests
EUR 911

Human Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) ELISA Kit
abx512995-96tests 96 tests
EUR 668

Mouse Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) ELISA Kit
abx512996-96tests 96 tests
EUR 668

Rat Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) ELISA Kit
abx512997-96tests 96 tests
EUR 668

Human EBAG9/ Receptor-binding cancer antigen expressed on SiSo cells ELISA Kit
E0748Hu 1 Kit
EUR 571

Human receptor-binding cancer antigen expressed on SiSo cells?RCAS1 ELISA kit
201-12-2019 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Leucine Zipper Protein Down-Regulated In Cancer Cells (LDOC1) ELISA Kit
abx388251-96tests 96 tests
EUR 911

Human receptor-binding cancer antigen expressed on SiSo cells(RCAS1)ELISA Kit
QY-E04136 96T
EUR 394

Human Cancer PrimaCell8: Glioma Cells Growth Supplements with Serum (for 500 ml medium)
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Dendritic Cells/B Cells Antibody
abx412775-02mg 0.2 mg
EUR 565

anti-CD45 RA B-cells, T-cells, NK-cells
516-A-01mg 0,1 mg
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Human Cancer Antigen CA125 (Ovarian Cancer) Protein
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EUR 1205

Human Cancer PrimaCell1: Esophageal Tumor Cells Growth Supplements with Serum (for 500 ml medium)
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5637 cells
C0002001 One Frozen vial
EUR 485

MB49 cells
C0002004 One Frozen vial
EUR 777

K562 cells
C0003004 One Frozen vial
EUR 455

U937 cells
C0003005 One Frozen vial
EUR 455

Raji cells
C0003009 One Frozen vial
EUR 455

Daudi cells
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RS4;11 cells
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EUR 455

NAMALWA cells
C0003013 One Frozen vial
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BJAB cells
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EUR 543

FO cells
C0003017 One Frozen vial
EUR 485

MC116 cells
C0003021 One Frozen vial
EUR 485

P3X63Ag8.653 cells
C0003028 One Frozen vial
EUR 455

REH cells
C0003031 One Frozen vial
EUR 485

Mino cells
C0003033 One Frozen vial
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U87MG cells
C0005002 One Frozen vial
EUR 455

B103 cells
C0005003 One Frozen vial
EUR 777

T47D cells
C0006001 One Frozen vial
EUR 455

4T1 cells
C0006004 One Frozen vial
EUR 455

HeLa cells
C0008001 One Frozen vial
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SiHa cells
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EUR 455

C33A cells
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EUR 455

CaSKi cells
C0008004 One Frozen vial
EUR 455

SW480 cells
C0009001 One Frozen vial
EUR 455

SW620 cells
C0009002 One Frozen vial
EUR 455

T84 cells
C0009008 One Frozen vial
EUR 455

HCT15 cells
C0009010 One Frozen vial
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LoVo cells
C0009011 One Frozen vial
EUR 455

RKO cells
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EUR 455

SW48 cells
C0009014 One Frozen vial
EUR 455

SW1116 cells
C0009019 One Frozen vial
EUR 455

H716 cells
C0009022 One Frozen vial
EUR 543

OE33 cells
C0013003 One Frozen vial
EUR 660

JROECL33 cells
C0013004 One Frozen vial
EUR 660

Hep3B cells
C0015001 One Frozen vial
EUR 455

HepG2 cells
C0015002 One Frozen vial
EUR 455

Calu3 cells
C0016001 One Frozen vial
EUR 455

A549 cells
C0016002 One Frozen vial
EUR 455

H460 cells
C0016003 One Frozen vial
EUR 455

A427 cells
C0016004 One Frozen vial
EUR 455

H23 cells
C0016005 One Frozen vial
EUR 455

H1703 cells
C0016008 One Frozen vial
EUR 543

SW1573 cells
C0016009 One Frozen vial
EUR 543

H520 cells
C0016010 One Frozen vial
EUR 455

H226 cells
C0016011 One Frozen vial
EUR 455

HCC4006 cells
C0016012 One Frozen vial
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H1975 cells
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EUR 543

H1650 cells
C0016015 One Frozen vial
EUR 543

H358 cells
C0016016 One Frozen vial
EUR 455

H2228 cells
C0016017 One Frozen vial
EUR 543

H2170 cells
C0016018 One Frozen vial
EUR 455

H441 cells
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EUR 455

H596 cells
C0016020 One Frozen vial
EUR 455

H1581 cells
C0016028 One Frozen vial
EUR 543

H2444 cells
C0016038 One Frozen vial
EUR 543

H69AR cells
C0016046 One Frozen vial
EUR 543

H1373 cells
C0016047 One Frozen vial
EUR 543

H2122 cells
C0016048 One Frozen vial
EUR 543

H526 cells
C0016052 One Frozen vial
EUR 455

H1299 cells
C0016053 One Frozen vial
EUR 455

The proliferation and migration skills of ESCs have been investigated by CCK8, transwell, and wound scratch assays. Endometrial OPN, p-PI3K, and uPA expressions and serum OPN ranges have been elevated in sufferers with endometriosis in contrast with the management. The expressions of p-PI3K, uPA, and α-tubulin have been decreased by siRNA-OPN interference in ectopic ESCs.

Activation and inhibition of the PI3K pathway apparently upregulate and downregulate uPA expression. Knockdown of OPN and inhibition of the PI3K pathway remarkably inhibited cell migration in ectopic ESCs.

In the meantime, activation of the PI3K pathway promoted the migration means of ectopic ESCs. OPN might regulate the expression of uPA by the PI3K sign pathway to have an effect on the migration means of ESCs, indicating that OPN, uPA, and the PI3K pathway could also be potential targets for interrupting improvement of endometriosis.