Response to „No evidence of SARS-CoV-2 infection by PCR or serology in children with pseudochilblain”

We read with interest the article by Caselli D et al., reporting a case series of 38 children with chilblain-like lesions (CLL). Testing for SARS-CoV-2, including PCR, rapid test serology and ELISA method for IgA and IgG antibodies yielded negative results in all cases. They concluded that their data do not allow them to support the relationship of CLL with SARS-CoV-2 infection. So far, data in the literature studying CLL documented a very low percentage of laboratory confirmed SARS-CoV-2. However, Colmenero and colleagues were able to detect SARS-CoV-2 in endothelial cells of cutaneous chilblain lesions by immunohistochemistry methods in 7 pediatric patients with negative nasopharyngeal swabs.

Orphan GPCR SP9155 agonist P550 (mouse, rat)

T40685-1mg 1mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat)

Orphan GPCR SP9155 agonist P550 (mouse, rat)

T40685-50mg 50mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat)

Orphan GPCR SP9155 agonist P550 (mouse, rat)

T40685-5mg 5mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat)

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

T40685L-10mg 10mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

T40685L-1g 1g Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

T40685L-1mg 1mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

T40685L-50mg 50mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

T40685L-5mg 5mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

Phosphatase Orphan-1 (Recombinant)

20-abx073910
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  • 10 ug
  • 1 mg
  • 2 µg

Phosphatase Orphan-2 (Recombinant)

20-abx073747
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  • Ask for price
  • 10 ug
  • 1 mg
  • 2 µg

TR3 Orphan Receptor Antibody

GWB-Q00589 0.1 mg Ask for price

Phosphatase Orphan-2 Human Recombinant

rAP-1526 Inquiry Ask for price

Phosphatase Orphan-1 Human Recombinant

rAP-1537 Inquiry Ask for price

Orphan Receptor Peptide Ligand Library

L-005 150 peptides
EUR 7938

Anti- Orphan nuclear receptor NR6A1 Antibody

GWB-523200 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR1D1 Antibody

GWB-797370 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR6A1 Antibody

GWB-7EBAAA 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR5A2 Antibody

GWB-83F95E 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR1D1 Antibody

GWB-8CE768 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR1D1 Antibody

GWB-90CFB3 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR1D2 Antibody

GWB-692AC1 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR6A1 Antibody

GWB-F872CA 0.05 ml Ask for price

PHOSPHO2 Phosphatase Orphan-2 Human Recombinant Protein

PROTQ8TCD6 Regular: 10ug
EUR 380.4
Description: PHOSPHO2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 265 amino acids (1-241) and having a molecular mass of 30.3kDa.;PHOSPHO2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

PHOSPHO1 Phosphatase Orphan-1 Human Recombinant Protein

PROTQ8TCT1 Regular: 10ug
EUR 380.4
Description: Human Phospho1 Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 295 amino acids and having a molecular mass of 31.3 kDa. The Human Phospho1 is fused to a 14 aa His tag at N-Terminus. Human Phosphocholine Phosphatase is purified by proprietary chromatographic techniques.

Anti- Orphan nuclear receptor EAR-2 Antibody

GWB-835BD4 0.05 ml Ask for price

Anti- Orphan nuclear receptor EAR-2 Antibody

GWB-8AE8C4 0.05 ml Ask for price

Anti- Orphan nuclear receptor EAR-2 Antibody

GWB-B9F321 0.05 ml Ask for price

Anti- Orphan nuclear receptor EAR-2 Antibody

GWB-D37B4B 0.05 ml Ask for price

RAR Related Orphan Receptor Gamma (RORG) Protein

20-abx261968
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  • 1 mg
  • 20 ug
  • 5 ug

RAR Related Orphan Receptor Beta (RORB) Antibody

20-abx214131
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  • 100 ul
  • 50 ul

RAR Related Orphan Receptor Beta (RORB) Antibody

20-abx214132
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  • 100 ul
  • 50 ul

RAR Related Orphan Receptor Beta (RORB) Antibody

abx237388-100ug 100 ug
EUR 610.8

Rar-Related Orphan Receptor A (RORA) Antibody

20-abx115045
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  • 150 ul
  • 50 ul

Rar-Related Orphan Receptor B (RORB) Antibody

20-abx115046
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  • 150 ul
  • 50 ul

Rar-Related Orphan Receptor C (RORC) Antibody

20-abx115047
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  • 150 ul
  • 50 ul

RAR Related Orphan Receptor Beta (RORB) Antibody

abx027769-400ul 400 ul
EUR 627.6

RAR Related Orphan Receptor Beta (RORB) Antibody

abx027769-80l 80 µl
EUR 343.2

Anti- RAR-related orphan receptor B Antibody

GWB-B1C150 0.05 ml Ask for price

Anti- RAR-related orphan receptor B Antibody

GWB-B781E5 0.05 ml Ask for price

Anti- RAR-related orphan receptor B Antibody

GWB-DA40DA 0.05 ml Ask for price

RAR Related Orphan Receptor Beta (RORB) Antibody

abx237388-100g 100 µg
EUR 350

Rar-Related Orphan Receptor A (RORA) Antibody

abx115045-100l 100 µl
EUR 612.5

Rar-Related Orphan Receptor B (RORB) Antibody

abx115046-100l 100 µl
EUR 612.5

Rar-Related Orphan Receptor C (RORC) Antibody

abx115047-100l 100 µl
EUR 612.5

RAR Related Orphan Receptor Beta (RORB) Antibody

abx027769-400l 400 µl
EUR 518.75

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214131-100l 100 µl
EUR 350

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214131-200l 200 µl Ask for price

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214131-40l 40 µl
EUR 250

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214132-100l 100 µl
EUR 350

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214132-200l 200 µl Ask for price

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214132-40l 40 µl
EUR 250

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx338779
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx325108
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  • 100 ug
  • 50 ug

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

20-abx130085
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx211380
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  • 100 ul
  • 50 ul

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

20-abx173779
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  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx174332
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  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx174333
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  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx178212
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  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx237387-100ug 100 ug
EUR 610.8

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx119555
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  • Ask for price
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

RAR Related Orphan Receptor Alpha (RORa) Antibody

20-abx103508
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  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx103509
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  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx005288
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  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

RAR Related Orphan Receptor Gamma (RORG) Antibody

20-abx013514
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  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx025951-400ul 400 ul
EUR 627.6

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx025951-80l 80 µl
EUR 343.2

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx005288-100l 100 µl
EUR 400

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx005288-20l 20 µl
EUR 175

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx005288-50l 50 µl
EUR 275

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx013514-100g 100 µg
EUR 237.5

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx013514-10g 10 µg
EUR 43.75

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx013514-200g 200 µg
EUR 312.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx237387-100g 100 µg
EUR 350

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

abx130085-100l 100 µl
EUR 287.5

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

abx130085-1ml 1 ml
EUR 812.5

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

abx130085-200l 200 µl
EUR 362.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx119555-100l 100 µl
EUR 312.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx119555-20l 20 µl
EUR 43.75

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx119555-50l 50 µl
EUR 237.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx025951-400l 400 µl
EUR 518.75

RAR Related Orphan Receptor Alpha (RORa) Antibody

abx103508-100g 100 µg
EUR 750

RAR Related Orphan Receptor Alpha (RORa) Antibody

abx103508-20g 20 µg
EUR 275

RAR Related Orphan Receptor Alpha (RORa) Antibody

abx103508-50g 50 µg
EUR 337.5

RAR Related Orphan Receptor Gamma (RORg) Antibody

abx103509-100g 100 µg
EUR 750

RAR Related Orphan Receptor Gamma (RORg) Antibody

abx103509-20g 20 µg
EUR 275

RAR Related Orphan Receptor Gamma (RORg) Antibody

abx103509-50g 50 µg
EUR 337.5

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx217274-100tests 100 tests Ask for price

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx217274-200tests 200 tests Ask for price

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx217274-20tests 20 tests
EUR 350

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

abx173779-1ml 1 ml
EUR 850

RAR Related Orphan Receptor Gamma (RORg) Antibody

abx174332-1ml 1 ml
EUR 787.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx211380-100l 100 µl
EUR 350

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx211380-50l 50 µl
EUR 250

RAR Related Orphan Receptor Gamma (RORg) Antibody

abx178212-96tests 96 tests
EUR 287.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx325108-100g 100 µg
EUR 250

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx325108-50g 50 µg
EUR 187.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx338779-100g 100 µg
EUR 362.5

Complement C4 Gene Copy Number Variation Genotyping by High Resolution Melting PCR

Background: Complement C4 gene copy number variation plays an important role as a determinant of genetic susceptibility to common diseases, such as systemic lupus erythematosus, schizophrenia, rheumatoid arthritis, and infectious diseases. This study aimed to develop an assay for the quantification of copy number variations in the C4 locus.

Methods: the assay was based on a gene ratio analysis copy enumeration (GRACE) PCR combined with high resolution melting (HRM) PCR. The test was optimized using samples of a known genotype and validated with 72 DNA samples from healthy blood donors.

Results: to validate the assay, standard curves were generated by plotting the C4/RP1 ratio values against copy number variation (CNV) for each gene, using genomic DNA with known C4 CNV. The range of copy numbers in control individuals was comparable to distributions observed in previous studies of European descent.

Conclusions: the method herein described significantly simplifies C4 CNV diagnosis to validate the assay.

Detection of BRAF V600E Mutation in Ganglioglioma and Pilocytic Astrocytoma by Immunohistochemistry and Real-Time PCR-Based Idylla Test

The BRAF V600E mutation is an important oncological target in certain central nervous system (CNS) tumors, for which a possible application of BRAF-targeted therapy grows continuously. In the present study, we aim to determine the prevalence of BRAF V600E mutations in a series of ganglioglioma (GG) and pilocytic astrocytoma (PA) cases. Simultaneously, we decided to verify whether the combination of fully automated tests-BRAF-VE1 immunohistochemistry (IHC) and Idylla BRAF mutation assay-may be useful to accurately predict it in the case of specified CNS tumors.

The study included 49 formalin-fixed, paraffin-embedded tissues, of which 15 were GG and 34 PA. Immunohistochemistry with anti-BRAF V600E (VE1) antibody was performed on tissue sections using the VentanaBenchMark ULTRA platform. All positive or equivocal cases on IHC and selected negative ones were further assessed using the Idylla BRAF mutation assay coupled with the Idylla platform. The BRAF-VE1 IHC was positive in 6 (6/49; 12.3%) and negative in 39 samples (39/49; 79.6%). The interpretation of immunostaining results was complicated in 4 cases, of which 1 tested positive for the Idylla BRAF mutation assay. Therefore, the overall positivity rate was 14.3%. This included 2 cases of GG and 5 cases of PA. Our study found that BRAF V600E mutations are moderately frequent in PA and GG and that for these tumor entities, IHC VE1 is suitable for screening purposes, but all negative, equivocal, and weak positive cases should be further tested with molecular biology techniques, of which the Idylla system seems to be a promising tool.

Establishment of an SYBR Green-based real-time PCR assay for porcine circovirus type 4 detection

Porcine circovirus 4 (PCV4) is a novel circovirus first discovered in China in April 2019. Here, we established an SYBR Green I-based real-time PCR for quantitative detection of PCV4. A pair of specific primers was designed based on the conserved region of Cap of PCV4. The standard curve of the established real-time PCR assay showed a good linear relationship.

The sensitivity of the established real-time PCR was 100 times greater than that of conventional PCR, and the detection limit of the assay was 3 × 101 copies. There was no cross-reactivity with other swine DNA viruses, showing good specificity. The intra-group variation coefficient was 0.37-0.78%, and the inter-group variation coefficient was 0.57-0.94%, indicating that the assay has good repeatability. Moreover, the analysis of clinical samples showed that the positive detection rate of PCV4 was 10.71% (18/168), while that of conventional PCR was 8.93% (15/168). Interestingly, co-infection with PCV2 or PCV3, or both PCV2 and PCV3, was also detected. In conclusion, the established SYBR Green I-based real-time PCR may be a cost-effective and rapid method for PCV4 clinical diagnosis.

Orphan GPCR SP9155 agonist P550 (mouse, rat)

T40685-5mg 5mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat)

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

T40685L-10mg 10mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

T40685L-1g 1g Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

T40685L-1mg 1mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

T40685L-50mg 50mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

T40685L-5mg 5mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

Phosphatase Orphan-1 (Recombinant)

20-abx073910
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  • 10 ug
  • 1 mg
  • 2 µg

Phosphatase Orphan-2 (Recombinant)

20-abx073747
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  • Ask for price
  • Ask for price
  • 10 ug
  • 1 mg
  • 2 µg

TR3 Orphan Receptor Antibody

GWB-Q00589 0.1 mg Ask for price

Phosphatase Orphan-2 Human Recombinant

rAP-1526 Inquiry Ask for price

Phosphatase Orphan-1 Human Recombinant

rAP-1537 Inquiry Ask for price

Orphan Receptor Peptide Ligand Library

L-005 150 peptides
EUR 7938

Anti- Orphan nuclear receptor NR6A1 Antibody

GWB-523200 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR1D1 Antibody

GWB-797370 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR6A1 Antibody

GWB-7EBAAA 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR5A2 Antibody

GWB-83F95E 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR1D1 Antibody

GWB-8CE768 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR1D1 Antibody

GWB-90CFB3 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR1D2 Antibody

GWB-692AC1 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR6A1 Antibody

GWB-F872CA 0.05 ml Ask for price

PHOSPHO2 Phosphatase Orphan-2 Human Recombinant Protein

PROTQ8TCD6 Regular: 10ug
EUR 380.4
Description: PHOSPHO2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 265 amino acids (1-241) and having a molecular mass of 30.3kDa.;PHOSPHO2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

PHOSPHO1 Phosphatase Orphan-1 Human Recombinant Protein

PROTQ8TCT1 Regular: 10ug
EUR 380.4
Description: Human Phospho1 Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 295 amino acids and having a molecular mass of 31.3 kDa. The Human Phospho1 is fused to a 14 aa His tag at N-Terminus. Human Phosphocholine Phosphatase is purified by proprietary chromatographic techniques.

Anti- Orphan nuclear receptor EAR-2 Antibody

GWB-835BD4 0.05 ml Ask for price

Anti- Orphan nuclear receptor EAR-2 Antibody

GWB-8AE8C4 0.05 ml Ask for price

Anti- Orphan nuclear receptor EAR-2 Antibody

GWB-B9F321 0.05 ml Ask for price

Anti- Orphan nuclear receptor EAR-2 Antibody

GWB-D37B4B 0.05 ml Ask for price

RAR Related Orphan Receptor Gamma (RORG) Protein

20-abx261968
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  • Ask for price
  • 1 mg
  • 20 ug
  • 5 ug

RAR Related Orphan Receptor Beta (RORB) Antibody

20-abx214131
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  • Ask for price
  • 100 ul
  • 50 ul

RAR Related Orphan Receptor Beta (RORB) Antibody

20-abx214132
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  • Ask for price
  • 100 ul
  • 50 ul

RAR Related Orphan Receptor Beta (RORB) Antibody

abx237388-100ug 100 ug
EUR 610.8

Rar-Related Orphan Receptor A (RORA) Antibody

20-abx115045
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  • 150 ul
  • 50 ul

Rar-Related Orphan Receptor B (RORB) Antibody

20-abx115046
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  • Ask for price
  • 150 ul
  • 50 ul

Rar-Related Orphan Receptor C (RORC) Antibody

20-abx115047
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  • Ask for price
  • 150 ul
  • 50 ul

RAR Related Orphan Receptor Beta (RORB) Antibody

abx027769-400ul 400 ul
EUR 627.6

RAR Related Orphan Receptor Beta (RORB) Antibody

abx027769-80l 80 µl
EUR 343.2

Anti- RAR-related orphan receptor B Antibody

GWB-B1C150 0.05 ml Ask for price

Anti- RAR-related orphan receptor B Antibody

GWB-B781E5 0.05 ml Ask for price

Anti- RAR-related orphan receptor B Antibody

GWB-DA40DA 0.05 ml Ask for price

RAR Related Orphan Receptor Beta (RORB) Antibody

abx237388-100g 100 µg
EUR 350

Rar-Related Orphan Receptor A (RORA) Antibody

abx115045-100l 100 µl
EUR 612.5

Rar-Related Orphan Receptor B (RORB) Antibody

abx115046-100l 100 µl
EUR 612.5

Rar-Related Orphan Receptor C (RORC) Antibody

abx115047-100l 100 µl
EUR 612.5

RAR Related Orphan Receptor Beta (RORB) Antibody

abx027769-400l 400 µl
EUR 518.75

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214131-100l 100 µl
EUR 350

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214131-200l 200 µl Ask for price

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214131-40l 40 µl
EUR 250

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214132-100l 100 µl
EUR 350

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214132-200l 200 µl Ask for price

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214132-40l 40 µl
EUR 250

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx338779
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  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx325108
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  • 100 ug
  • 50 ug

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

20-abx130085
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  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx211380
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  • 100 ul
  • 50 ul

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

20-abx173779
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  • Ask for price
  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx174332
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  • Ask for price
  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx174333
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  • Ask for price
  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx178212
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  • Ask for price
  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx237387-100ug 100 ug
EUR 610.8

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx119555
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  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

RAR Related Orphan Receptor Alpha (RORa) Antibody

20-abx103508
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  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx103509
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  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx005288
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  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

RAR Related Orphan Receptor Gamma (RORG) Antibody

20-abx013514
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  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx025951-400ul 400 ul
EUR 627.6

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx025951-80l 80 µl
EUR 343.2

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx005288-100l 100 µl
EUR 400

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx005288-20l 20 µl
EUR 175

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx005288-50l 50 µl
EUR 275

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx013514-100g 100 µg
EUR 237.5

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx013514-10g 10 µg
EUR 43.75

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx013514-200g 200 µg
EUR 312.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx237387-100g 100 µg
EUR 350

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

abx130085-100l 100 µl
EUR 287.5

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

abx130085-1ml 1 ml
EUR 812.5

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

abx130085-200l 200 µl
EUR 362.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx119555-100l 100 µl
EUR 312.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx119555-20l 20 µl
EUR 43.75

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx119555-50l 50 µl
EUR 237.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx025951-400l 400 µl
EUR 518.75

RAR Related Orphan Receptor Alpha (RORa) Antibody

abx103508-100g 100 µg
EUR 750

RAR Related Orphan Receptor Alpha (RORa) Antibody

abx103508-20g 20 µg
EUR 275

RAR Related Orphan Receptor Alpha (RORa) Antibody

abx103508-50g 50 µg
EUR 337.5

RAR Related Orphan Receptor Gamma (RORg) Antibody

abx103509-100g 100 µg
EUR 750

RAR Related Orphan Receptor Gamma (RORg) Antibody

abx103509-20g 20 µg
EUR 275

RAR Related Orphan Receptor Gamma (RORg) Antibody

abx103509-50g 50 µg
EUR 337.5

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx217274-100tests 100 tests Ask for price

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx217274-200tests 200 tests Ask for price

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx217274-20tests 20 tests
EUR 350

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

abx173779-1ml 1 ml
EUR 850

RAR Related Orphan Receptor Gamma (RORg) Antibody

abx174332-1ml 1 ml
EUR 787.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx211380-100l 100 µl
EUR 350

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx211380-50l 50 µl
EUR 250

Complement C4 Gene Copy Number Variation Genotyping by High Resolution Melting PCR

Background: Complement C4 gene copy number variation plays an important role as a determinant of genetic susceptibility to common diseases, such as systemic lupus erythematosus, schizophrenia, rheumatoid arthritis, and infectious diseases. This study aimed to develop an assay for the quantification of copy number variations in the C4 locus.

Methods: the assay was based on a gene ratio analysis copy enumeration (GRACE) PCR combined with high resolution melting (HRM) PCR. The test was optimized using samples of a known genotype and validated with 72 DNA samples from healthy blood donors.

Results: to validate the assay, standard curves were generated by plotting the C4/RP1 ratio values against copy number variation (CNV) for each gene, using genomic DNA with known C4 CNV. The range of copy numbers in control individuals was comparable to distributions observed in previous studies of European descent.

Conclusions: the method herein described significantly simplifies C4 CNV diagnosis to validate the assay.

Detection of BRAF V600E Mutation in Ganglioglioma and Pilocytic Astrocytoma by Immunohistochemistry and Real-Time PCR-Based Idylla Test

The BRAF V600E mutation is an important oncological target in certain central nervous system (CNS) tumors, for which a possible application of BRAF-targeted therapy grows continuously. In the present study, we aim to determine the prevalence of BRAF V600E mutations in a series of ganglioglioma (GG) and pilocytic astrocytoma (PA) cases. Simultaneously, we decided to verify whether the combination of fully automated tests-BRAF-VE1 immunohistochemistry (IHC) and Idylla BRAF mutation assay-may be useful to accurately predict it in the case of specified CNS tumors.

The study included 49 formalin-fixed, paraffin-embedded tissues, of which 15 were GG and 34 PA. Immunohistochemistry with anti-BRAF V600E (VE1) antibody was performed on tissue sections using the VentanaBenchMark ULTRA platform. All positive or equivocal cases on IHC and selected negative ones were further assessed using the Idylla BRAF mutation assay coupled with the Idylla platform. The BRAF-VE1 IHC was positive in 6 (6/49; 12.3%) and negative in 39 samples (39/49; 79.6%). The interpretation of immunostaining results was complicated in 4 cases, of which 1 tested positive for the Idylla BRAF mutation assay. Therefore, the overall positivity rate was 14.3%. This included 2 cases of GG and 5 cases of PA. Our study found that BRAF V600E mutations are moderately frequent in PA and GG and that for these tumor entities, IHC VE1 is suitable for screening purposes, but all negative, equivocal, and weak positive cases should be further tested with molecular biology techniques, of which the Idylla system seems to be a promising tool.

Establishment of an SYBR Green-based real-time PCR assay for porcine circovirus type 4 detection

Porcine circovirus 4 (PCV4) is a novel circovirus first discovered in China in April 2019. Here, we established an SYBR Green I-based real-time PCR for quantitative detection of PCV4. A pair of specific primers was designed based on the conserved region of Cap of PCV4. The standard curve of the established real-time PCR assay showed a good linear relationship. The sensitivity of the established real-time PCR was 100 times greater than that of conventional PCR, and the detection limit of the assay was 3 × 101 copies. There was no cross-reactivity with other swine DNA viruses, showing good specificity. The intra-group variation coefficient was 0.37-0.78%, and the inter-group variation coefficient was 0.57-0.94%, indicating that the assay has good repeatability. Moreover, the analysis of clinical samples showed that the positive detection rate of PCV4 was 10.71% (18/168), while that of conventional PCR was 8.93% (15/168). Interestingly, co-infection with PCV2 or PCV3, or both PCV2 and PCV3, was also detected. In conclusion, the established SYBR Green I-based real-time PCR may be a cost-effective and rapid method for PCV4 clinical diagnosis.

Orphan GPCR SP9155 agonist P550 (mouse, rat)

T40685-5mg 5mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat)

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

T40685L-10mg 10mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

T40685L-1g 1g Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

T40685L-1mg 1mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

T40685L-50mg 50mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

T40685L-5mg 5mg Ask for price
Description: Orphan GPCR SP9155 agonist P550 (mouse, rat) acetate

Phosphatase Orphan-1 (Recombinant)

20-abx073910
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  • 10 ug
  • 1 mg
  • 2 µg

Phosphatase Orphan-2 (Recombinant)

20-abx073747
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  • Ask for price
  • 10 ug
  • 1 mg
  • 2 µg

TR3 Orphan Receptor Antibody

GWB-Q00589 0.1 mg Ask for price

Phosphatase Orphan-2 Human Recombinant

rAP-1526 Inquiry Ask for price

Phosphatase Orphan-1 Human Recombinant

rAP-1537 Inquiry Ask for price

Orphan Receptor Peptide Ligand Library

L-005 150 peptides
EUR 7938

Anti- Orphan nuclear receptor NR6A1 Antibody

GWB-523200 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR1D1 Antibody

GWB-797370 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR6A1 Antibody

GWB-7EBAAA 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR5A2 Antibody

GWB-83F95E 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR1D1 Antibody

GWB-8CE768 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR1D1 Antibody

GWB-90CFB3 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR1D2 Antibody

GWB-692AC1 0.05 ml Ask for price

Anti- Orphan nuclear receptor NR6A1 Antibody

GWB-F872CA 0.05 ml Ask for price

PHOSPHO2 Phosphatase Orphan-2 Human Recombinant Protein

PROTQ8TCD6 Regular: 10ug
EUR 380.4
Description: PHOSPHO2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 265 amino acids (1-241) and having a molecular mass of 30.3kDa.;PHOSPHO2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

PHOSPHO1 Phosphatase Orphan-1 Human Recombinant Protein

PROTQ8TCT1 Regular: 10ug
EUR 380.4
Description: Human Phospho1 Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 295 amino acids and having a molecular mass of 31.3 kDa. The Human Phospho1 is fused to a 14 aa His tag at N-Terminus. Human Phosphocholine Phosphatase is purified by proprietary chromatographic techniques.

Anti- Orphan nuclear receptor EAR-2 Antibody

GWB-835BD4 0.05 ml Ask for price

Anti- Orphan nuclear receptor EAR-2 Antibody

GWB-8AE8C4 0.05 ml Ask for price

Anti- Orphan nuclear receptor EAR-2 Antibody

GWB-B9F321 0.05 ml Ask for price

Anti- Orphan nuclear receptor EAR-2 Antibody

GWB-D37B4B 0.05 ml Ask for price

RAR Related Orphan Receptor Gamma (RORG) Protein

20-abx261968
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  • 1 mg
  • 20 ug
  • 5 ug

RAR Related Orphan Receptor Beta (RORB) Antibody

20-abx214131
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  • 100 ul
  • 50 ul

RAR Related Orphan Receptor Beta (RORB) Antibody

20-abx214132
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  • 100 ul
  • 50 ul

RAR Related Orphan Receptor Beta (RORB) Antibody

abx237388-100ug 100 ug
EUR 610.8

Rar-Related Orphan Receptor A (RORA) Antibody

20-abx115045
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  • 150 ul
  • 50 ul

Rar-Related Orphan Receptor B (RORB) Antibody

20-abx115046
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  • 150 ul
  • 50 ul

Rar-Related Orphan Receptor C (RORC) Antibody

20-abx115047
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  • 150 ul
  • 50 ul

RAR Related Orphan Receptor Beta (RORB) Antibody

abx027769-400ul 400 ul
EUR 627.6

RAR Related Orphan Receptor Beta (RORB) Antibody

abx027769-80l 80 µl
EUR 343.2

Anti- RAR-related orphan receptor B Antibody

GWB-B1C150 0.05 ml Ask for price

Anti- RAR-related orphan receptor B Antibody

GWB-B781E5 0.05 ml Ask for price

Anti- RAR-related orphan receptor B Antibody

GWB-DA40DA 0.05 ml Ask for price

RAR Related Orphan Receptor Beta (RORB) Antibody

abx237388-100g 100 µg
EUR 350

Rar-Related Orphan Receptor A (RORA) Antibody

abx115045-100l 100 µl
EUR 612.5

Rar-Related Orphan Receptor B (RORB) Antibody

abx115046-100l 100 µl
EUR 612.5

Rar-Related Orphan Receptor C (RORC) Antibody

abx115047-100l 100 µl
EUR 612.5

RAR Related Orphan Receptor Beta (RORB) Antibody

abx027769-400l 400 µl
EUR 518.75

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214131-100l 100 µl
EUR 350

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214131-200l 200 µl Ask for price

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214131-40l 40 µl
EUR 250

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214132-100l 100 µl
EUR 350

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214132-200l 200 µl Ask for price

RAR Related Orphan Receptor Beta (RORB) Antibody

abx214132-40l 40 µl
EUR 250

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx338779
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx325108
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  • 100 ug
  • 50 ug

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

20-abx130085
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx211380
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  • 100 ul
  • 50 ul

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

20-abx173779
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  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx174332
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  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx174333
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  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx178212
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  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx237387-100ug 100 ug
EUR 610.8

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx119555
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  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

RAR Related Orphan Receptor Alpha (RORa) Antibody

20-abx103508
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx103509
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  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx005288
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

RAR Related Orphan Receptor Gamma (RORG) Antibody

20-abx013514
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  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx025951-400ul 400 ul
EUR 627.6

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx025951-80l 80 µl
EUR 343.2

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx005288-100l 100 µl
EUR 400

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx005288-20l 20 µl
EUR 175

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx005288-50l 50 µl
EUR 275

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx013514-100g 100 µg
EUR 237.5

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx013514-10g 10 µg
EUR 43.75

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx013514-200g 200 µg
EUR 312.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx237387-100g 100 µg
EUR 350

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

abx130085-100l 100 µl
EUR 287.5

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

abx130085-1ml 1 ml
EUR 812.5

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

abx130085-200l 200 µl
EUR 362.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx119555-100l 100 µl
EUR 312.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx119555-20l 20 µl
EUR 43.75

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx119555-50l 50 µl
EUR 237.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx025951-400l 400 µl
EUR 518.75

RAR Related Orphan Receptor Alpha (RORa) Antibody

abx103508-100g 100 µg
EUR 750

RAR Related Orphan Receptor Alpha (RORa) Antibody

abx103508-20g 20 µg
EUR 275

RAR Related Orphan Receptor Alpha (RORa) Antibody

abx103508-50g 50 µg
EUR 337.5

RAR Related Orphan Receptor Gamma (RORg) Antibody

abx103509-100g 100 µg
EUR 750

RAR Related Orphan Receptor Gamma (RORg) Antibody

abx103509-20g 20 µg
EUR 275

RAR Related Orphan Receptor Gamma (RORg) Antibody

abx103509-50g 50 µg
EUR 337.5

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx217274-100tests 100 tests Ask for price

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx217274-200tests 200 tests Ask for price

RAR Related Orphan Receptor Gamma (RORG) Antibody

abx217274-20tests 20 tests
EUR 350

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

abx173779-1ml 1 ml
EUR 850

RAR Related Orphan Receptor Gamma (RORg) Antibody

abx174332-1ml 1 ml
EUR 787.5

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx211380-100l 100 µl
EUR 350

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx211380-50l 50 µl
EUR 250